Debaser by Pixies - Before the Pixies, I thought most of what passed for college alternative music sucked. But I heard this band live in Boston and it changed everything. It was a band that could sing about nothing and make it rock.
Debaser was the opening track off the Doolittle album, and it kicks things into high gear. It is about a Luis Bunuel movie that happened to be about nothing in particular. And how can you not like a song with these opening lyrics:
Got me a movie I want you to know Slicing up eyeballs I want you to know